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Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma.

Pavlina ChuntovaAkane YamamichiTiffany ChenRohini NarayanaswamySebastien RonseauxChristine HudsonAdriana E TronMarc L HyerMegan MontoyaAbigail L MendeTakahide NejoKira M DowneyDavid DieboldMin LuBrandon NicolayHideho Okada
Published in: Journal for immunotherapy of cancer (2022)
glioma model should allow us to evaluate key translational questions related to the development of novel strategies for patients with IDH-mutant glioma.
Keyphrases
  • wild type
  • mouse model
  • low grade
  • cell proliferation
  • poor prognosis
  • genome wide
  • signaling pathway
  • gene expression
  • dna methylation
  • long non coding rna
  • fluorescent probe
  • drug induced