Inhibition of D-2HG leads to upregulation of a proinflammatory gene signature in a novel HLA-A2/HLA-DR1 transgenic mouse model of IDH1R132H-expressing glioma.
Pavlina ChuntovaAkane YamamichiTiffany ChenRohini NarayanaswamySebastien RonseauxChristine HudsonAdriana E TronMarc L HyerMegan MontoyaAbigail L MendeTakahide NejoKira M DowneyDavid DieboldMin LuBrandon NicolayHideho OkadaPublished in: Journal for immunotherapy of cancer (2022)
glioma model should allow us to evaluate key translational questions related to the development of novel strategies for patients with IDH-mutant glioma.