A systematic review and meta-analysis of the impact of cornelian cherry consumption on blood lipid profiles.
Keyhan MohammadiMahmood Alizadeh SaniElyas Nattagh-EshtivaniShakila YaribashJamal RahmaniBehdad Shokrollahi YancheshmehDavid Julian McClementsPublished in: Food science & nutrition (2021)
Polyphenolic and flavonoid compounds are claimed to improve blood lipid profiles and to provide protective effects against cardiovascular disease. For this reason, we conducted a systematic review and meta-analysis of studies that comprehensively investigated the effects of cornelian cherry supplementation on lipid profiles in rat models. Up to December 2020, 855 articles were screened, and finally, seven articles were selected as eligible for the meta-analysis. This meta-analysis revealed that cornelian cherry supplementation significantly decreased low-density lipoprotein (LDL) (WMD = -6.38 mg/dl; 95% CI, -9.93 to-2.84; p < .001), triglyceride (TG) (WMD = -52.36 mg/dl; 95% CI, -80.50 to -24.22; p < .005), and cholesterol level (WMD = -37.16 mg/dl; 95% CI, -51.19 to -23.13; p < .005) in treated rats compared with control groups. A nonsignificant increase in high-density lipoprotein (HDL) level was observed (WMD = 4.21 mg/dl; 95% CI, -3.25 to 11.66; p = .268). These results suggest that cherry supplementation may have health effects by modifying lipid profiles. However, there is a need for more well-controlled human clinical trials to make more definitive conclusions about the potential health benefits of cherry supplementation.
Keyphrases
- low density lipoprotein
- systematic review
- high density
- cardiovascular disease
- clinical trial
- fatty acid
- case control
- meta analyses
- healthcare
- public health
- mental health
- type diabetes
- squamous cell carcinoma
- oxidative stress
- single cell
- randomized controlled trial
- risk assessment
- cardiovascular risk factors
- high resolution
- mass spectrometry
- locally advanced
- atomic force microscopy
- health promotion