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Identifying novel ovarian tumor biomarkers through mining of the transcriptome of circulating immune cells: A proof-of-concept study.

Shitanshu UppalErin MedlinMildred FelderArvinder KapurRobert C SternerJessica VazquezPayton N LindnerAleksandar K StanicLisa BarroilhetJesus Gonzalez-BosquetManish Suresh Patankar
Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2021)
The PBMC transcriptome shows longitudinal changes in response to the progressing tumor. Several potential biomarker transcripts were identified in HGSOC patients and mouse models. Monitoring their expression in individual PBMC subsets can serve as additional discriminator for the diagnosis of HGSOC.
Keyphrases
  • rna seq
  • gene expression
  • newly diagnosed
  • ejection fraction
  • single cell
  • mouse model
  • genome wide
  • poor prognosis
  • prognostic factors
  • cross sectional
  • peripheral blood
  • chronic kidney disease
  • patient reported