Enhanced lipid biosynthesis in human tumor-induced macrophages contributes to their protumoral characteristics.

Katrin RaboldAnna AschenbrennerChristoph ThieleCollins K BoahenAlexander SchiltmansJohannes W A SmitJoachim L SchultzeMihai G NeteaGosse J AdemaRomana T Netea-Maier

Published in: Journal for immunotherapy of cancer (2021)

Taken together, our data show that tumor cells can stimulate lipid biosynthesis in macrophages to induce protumoral cytokine and ROS responses and advocate lipid biosynthesis as a potential therapeutic target to reprogram the TME.

Keyphrases

cell wall
fatty acid
endothelial cells
high glucose
cell death
electronic health record
dna damage
diabetic rats
big data
reactive oxygen species
oxidative stress
risk assessment
deep learning
artificial intelligence
pluripotent stem cells
data analysis