Pharos 2023: an integrated resource for the understudied human proteome.
Keith J KelleherTimothy K SheilsStephen L MathiasJeremy J YangVincent T MetzgerVishal B SiramshettyÐắc-Trung NguyễnLars Juhl JensenDušica VidovićStephan C SchürerJayme HolmesKarlie R SharmaAjay PillaiCristian G BologaJeremy S EdwardsEwy A MathTudor I OpreaPublished in: Nucleic acids research (2023)
The Illuminating the Druggable Genome (IDG) project aims to improve our understanding of understudied proteins and our ability to study them in the context of disease biology by perturbing them with small molecules, biologics, or other therapeutic modalities. Two main products from the IDG effort are the Target Central Resource Database (TCRD) (http://juniper.health.unm.edu/tcrd/), which curates and aggregates information, and Pharos (https://pharos.nih.gov/), a web interface for fusers to extract and visualize data from TCRD. Since the 2021 release, TCRD/Pharos has focused on developing visualization and analysis tools that help reveal higher-level patterns in the underlying data. The current iterations of TCRD and Pharos enable users to perform enrichment calculations based on subsets of targets, diseases, or ligands and to create interactive heat maps and UpSet charts of many types of annotations. Using several examples, we show how to address disease biology and drug discovery questions through enrichment calculations and UpSet charts.
Keyphrases
- drug discovery
- density functional theory
- electronic health record
- molecular dynamics
- endothelial cells
- molecular dynamics simulations
- healthcare
- big data
- genome wide
- public health
- health information
- mental health
- oxidative stress
- quality improvement
- gene expression
- dna methylation
- peripheral blood
- single cell
- machine learning
- emergency department
- adverse drug
- data analysis