Identification of long non-coding RNA-mRNA interactions and genome-wide lncRNA annotation in animal transcriptome profiling.
Yoon-Been ParkJun-Mo KimPublished in: Journal of animal science and technology (2023)
Protein-translated mRNA analysis has been extensively used to determine the function of various traits in animals. The non-coding RNA (ncRNA), which was known to be non-functional because it was not encoded as a protein, was re-examined as it was studied to actually function. One of the ncRNAs, long non-coding RNA (lncRNA), is known to have a function of regulating mRNA expression, and its importance is emerging. Therefore, lncRNAs are currently being used to understand the traits of various animals as well as human diseases. However, studies on lncRNA annotation and its functions are still lacking in most animals except humans and mice. lncRNAs have unique characteristics of lncRNAs and interact with mRNA through various mechanisms. In order to make lncRNA annotations in animals in the future, it is essential to understand the characteristics of lncRNAs and the mechanisms by which lncRNAs function. In addition, this will allow lncRNAs to be used for a wider variety of traits in a wider range of animals, and it is expected that integrated analysis using other biological information will be possible.
Keyphrases
- long non coding rna
- genome wide
- poor prognosis
- network analysis
- genome wide analysis
- genome wide identification
- binding protein
- dna methylation
- rna seq
- endothelial cells
- adipose tissue
- single cell
- gene expression
- multidrug resistant
- copy number
- type diabetes
- healthcare
- small molecule
- metabolic syndrome
- current status
- health information
- data analysis
- pluripotent stem cells