Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
Shuai ZhangOrnella D NelsonIan R PriceChengliang ZhuXuan LuIrma R FernandezRobert Samuel WeissHening LinPublished in: Proceedings of the National Academy of Sciences of the United States of America (2022)
SignificanceThe study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discovering other regulatory mechanisms of protein function by small molecule metabolites.