Safety and Effectiveness of High-Intensity Statins Versus Low/Moderate-Intensity Statins Plus Ezetimibe in Patients With Atherosclerotic Cardiovascular Disease for Reaching LDL-C Goals: A Systematic Review and Meta-Analysis.
Hamidreza SoleimaniAsma MousaviShayan ShojaeiKiarash TavakoliDorsa SalabatFarid Farahani RadMani K AskariJohn NelsonMohammad RuziehKaveh HosseiniPublished in: Clinical cardiology (2024)
Adding ezetimibe to low/moderate-intensity statins resulted in a greater reduction in LDL-C levels, a lower rate of myalgia, and less drug discontinuation compared to high-intensity statin monotherapy in patients with existing cardiovascular disease. However, according to our meta-analysis, the observed reduction in LDL-C levels in the combination group did not correlate with a reduction in MACE compared to the high-intensity statin group.
Keyphrases
- high intensity
- cardiovascular disease
- systematic review
- resistance training
- low density lipoprotein
- cardiovascular events
- cardiovascular risk factors
- type diabetes
- randomized controlled trial
- open label
- metabolic syndrome
- clinical trial
- emergency department
- body composition
- combination therapy
- public health
- study protocol
- global health
- double blind