Genomic, Transcriptomic, and Proteomic Profiling of Metastatic Breast Cancer.

Argun AkcakanatXiaofeng ZhengChristian X Cruz-PicoTae-Beom KimKen ChenAnil KorkutAysegul SahinVijaykumar HollaEmily TarcoGopal SinghSenthil DamodaranGordon B MillsAna Maria Gonzalez-AnguloFunda Meric-Bernstam

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Molecular profiling in MBC reveals multiple common as well as less frequent but potentially actionable alterations. Genomic and transcriptional profiling demonstrates intertumoral heterogeneity and potential evolution of actionable targets with tumor progression. Further work is needed to optimize testing and integrated analysis for treatment selection.

Keyphrases

single cell
metastatic breast cancer
rna seq
copy number
gene expression
poor prognosis
transcription factor
single molecule
heat shock
climate change
genome wide