Macronutrient Intake-Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial.
Yoriko HeianzaWenjie MaTao HuangTiange WangYan ZhengSteven R SmithGeorge A BrayFrank M SacksLu QiPublished in: Diabetes care (2016)
Our data suggest that FGF21 genotypes may interact with dietary carbohydrate/fat intake on changes in central adiposity and body fat composition. A low-calorie, high-carbohydrate/low-fat diet was beneficial for overweight or obese individuals carrying the carbohydrate intake-decreasing allele of the FGF21 variant to improve body composition and abdominal obesity.
Keyphrases
- weight loss
- body composition
- weight gain
- bariatric surgery
- roux en y gastric bypass
- resistance training
- adipose tissue
- gastric bypass
- bone mineral density
- insulin resistance
- glycemic control
- obese patients
- body mass index
- fatty acid
- phase iii
- metabolic syndrome
- randomized controlled trial
- type diabetes
- phase ii
- postmenopausal women
- open label