Altered high-density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross-sectional, case-control study on lipoprotein subclass profiling.

Lushun Yuan Ruifang Li-Gao Aswin Verhoeven Huub J van Eyk Maurice B Bizino Patrick C N Rensen Martin A Giera Ingrid M Jazet Hildo J Lamb Ton J Rabelink Bernard M van den Berg

Published in: Diabetes, obesity & metabolism (2023)

While HDL composition differed between controls and T2DM in both ethnic groups, the lower levels of lipid content in the smallest HDL subclass (HDL-4) in DSA with T2DM appeared to be more clinically relevant, with higher odds of having diabetes-related pan-microvascular complications such as retinopathy and neuropathy. These typical differences in HDL could be used as ethnicity-specific T2DM biomarkers.

Keyphrases

high density
glycemic control
type diabetes
metabolic syndrome
adipose tissue
low density lipoprotein
fatty acid