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Altered high-density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross-sectional, case-control study on lipoprotein subclass profiling.

Lushun YuanRuifang Li-GaoAswin VerhoevenHuub J van EykMaurice B BizinoPatrick C N RensenMartin A GieraIngrid M JazetHildo J LambTon J RabelinkBernard M van den Berg
Published in: Diabetes, obesity & metabolism (2023)
While HDL composition differed between controls and T2DM in both ethnic groups, the lower levels of lipid content in the smallest HDL subclass (HDL-4) in DSA with T2DM appeared to be more clinically relevant, with higher odds of having diabetes-related pan-microvascular complications such as retinopathy and neuropathy. These typical differences in HDL could be used as ethnicity-specific T2DM biomarkers.
Keyphrases
  • high density
  • glycemic control
  • type diabetes
  • metabolic syndrome
  • adipose tissue
  • low density lipoprotein
  • fatty acid