Altered high-density lipoprotein composition is associated with risk for complications in type 2 diabetes mellitus in South Asian descendants: A cross-sectional, case-control study on lipoprotein subclass profiling.
Lushun YuanRuifang Li-GaoAswin VerhoevenHuub J van EykMaurice B BizinoPatrick C N RensenMartin A GieraIngrid M JazetHildo J LambTon J RabelinkBernard M van den BergPublished in: Diabetes, obesity & metabolism (2023)
While HDL composition differed between controls and T2DM in both ethnic groups, the lower levels of lipid content in the smallest HDL subclass (HDL-4) in DSA with T2DM appeared to be more clinically relevant, with higher odds of having diabetes-related pan-microvascular complications such as retinopathy and neuropathy. These typical differences in HDL could be used as ethnicity-specific T2DM biomarkers.