Marine Microalgal Products with Activities against Age-Related Cardiovascular Diseases.
Nova YurikaEleonora MontuoriChiara LauritanoPublished in: Marine drugs (2024)
Heart disease is one of the leading causes of death worldwide, and it is estimated that 17.9 million people die of it each year. The risk factors for cardiovascular diseases are attributable to an unhealthy and sedentary lifestyle, poor nutrition, stress, genetic predisposition, diabetes, obesity, and aging. Marine microalgae have been the subject of numerous studies for their potential activity against several human diseases. They produce a plethora of primary and secondary metabolites such as essential nutrients, vitamins, pigments, and omega-3 fatty acid. Many of these molecules have antioxidant properties and have been shown to play a role in the prevention of heart diseases. The aim of this review is to summarize recent studies on the discovery of marine microalgal compounds and bioactivities for cardiovascular diseases, including in vitro and in vivo studies, showing and discussing recent discoveries and trends. The most promising results were found for microalgal polysaccharides, peptides and carotenoids. In conclusion, the overall data summarized here show that microalgae-based supplementation has the potential to improve age-related cardiovascular diseases and we expect more clinical studies in the future.
Keyphrases
- cardiovascular disease
- physical activity
- type diabetes
- case control
- fatty acid
- metabolic syndrome
- cardiovascular risk factors
- endothelial cells
- weight loss
- oxidative stress
- heart failure
- pulmonary hypertension
- gene expression
- atrial fibrillation
- big data
- human health
- heavy metals
- high throughput
- electronic health record
- anaerobic digestion
- induced pluripotent stem cells
- anti inflammatory
- deep learning
- machine learning
- skeletal muscle
- heat stress
- glycemic control
- high fat diet induced
- pluripotent stem cells
- single cell
- body mass index
- dna methylation