Global incidence of intrahepatic cholestasis of pregnancy: A protocol for systematic review and meta-analysis.

Estimating the global and regional prevalence of ICP and evaluating the effects of moderating factors will provide valuable insights into the knowledge. Further investigations on the moderating factors will help researchers to hypothesize the associations and extend the current understanding of the disease. The planned study will be the first systematic review and meta-analysis that estimates the global prevalence of ICP. The reviewers will try rigorous mythology to ensure high-quality evidence. However, substantial heterogeneity is expected as prevalence studies utilize different mythologies, settings, and definitions. Moreover, this study relies on utilizing previously published studies, which may impede the overall data quality and comprehensiveness.