Protective Roles of Thymoquinone Nanoformulations: Potential Nanonutraceuticals in Human Diseases.
Ali H El-FarSoad Khalil Al JaouniWeikun LiShaker A MousaPublished in: Nutrients (2018)
The focus on nanotechnology for improved bioavailability and drug delivery is of increasing importance for control of different human diseases. Therefore, numerous nanoformulations have been developed for the oral bioavailability of different drugs. This review introduces applications of nanomedicine to enhance the biological activities of thymoquinone (TQ) to control different diseases in several in vivo studies as a preliminary investigation for human disease treatment with nano-TQ. Nano-TQ effectively augments the anticancer roles of doxorubicin by upregulation of P53 and downregulation of Bcl2 and potentiates paclitaxel's apoptosis in MCF-7 breast cancer cells. Moreover, nano-TQ protects against diabetes, inflammation, CNS, and hepatotoxicity, mainly by enhancement of organs' antioxidant status. We summarize the pros and cons of several FDA approved nanoparticle-based therapeutics and discuss the roadblocks in clinical translation, along with potential nano-TQ strategies to overcome these roadblocks. From this review, we can conclude that nano-TQ may be considered as a promising nutraceutical for human health.
Keyphrases
- human health
- endothelial cells
- drug delivery
- oxidative stress
- breast cancer cells
- risk assessment
- induced pluripotent stem cells
- type diabetes
- cardiovascular disease
- cancer therapy
- pluripotent stem cells
- cell proliferation
- small molecule
- climate change
- signaling pathway
- poor prognosis
- endoplasmic reticulum stress
- cell death
- skeletal muscle