Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.
Katia K MattisNicole A J KrentzChristoph MetzendorfFernando AbaituaAliya F SpigelmanHanice SunJennifer M IkleSwaraj ThamanAntje K GrotzAustin BautistaEugenia MazzaferroMarta Perez-AlcantaraJocelyn E Manning FoxJason M TorresAgata Wesolowska-AndersenGrace Z YuAnubha MahajanAnders O LarssonPatrick Edward MacDonaldBenjamin DaviesMarcel den HoedAnna L GloynPublished in: Diabetologia (2023)
Together, our results indicate that RREB1 regulates beta cell function by transcriptionally regulating the expression of genes involved in beta cell development and function.