Patrick Edward MacDonald (Patrick E MacDonald)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 31

Top Venues

Diabetologia

Nature communications

Biomolecules

bioRxiv : the preprint server for biology

University of Alberta

University of Toronto (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Alberta Jul 01 2006

Canada

Professor :: Pharmacology

University of Oxford Jul 01 2005 - Jun 30 2006

United Kingdom

Postdoctoral Fellow :: Oxford Centre for Diabetes, Endorinology, and Metabolism

Lund University Jul 01 2003 - Jun 30 2005

Sweden

Postdoctoral Fellow

Education History

University of Toronto Sep 01 1998 - May 31 2003

Canada

PHD :: Physiology

Publications

Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F Spigelman, Xiao-Qing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R Pepper, Leticia Prates Roma, Emmanuel Ampofo, Wen-Hong Li, Patrick Edward MacDonald
A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding. Nature communications 15 (1) (2024)
Jessica D Ewald, Yao Lu, Cara E Ellis, Jessica Worton, Jelena Kolic, Shugo Sasaki, Dahai Zhang, Theodore Dos Santos, Aliya F Spigelman, Austin Bautista, Xiao-Qing Dai, James G Lyon, Nancy P Smith, Jordan M Wong, Varsha Rajesh, Han Sun, Seth A Sharp, Jason C Rogalski, Renata Moravcova, Haoning Howard Cen, Jocelyn E Manning Fox, Hi-DAS Consortium, Ella Atlas, Jennifer E Bruin, Erin E Mulvihill, C Bruce Verchere, Leonard J Foster, Anna L Gloyn, James D Johnson, Andrew R Pepper, Francis C Lynn, Jianguo Xia, Patrick Edward MacDonald
HumanIslets: An integrated platform for human islet data access and analysis. bioRxiv : the preprint server for biology (2024)
Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F Spigelman, Xiao-Qing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R Pepper, Leticia Prates Roma, Emmanuel Ampofo, Wen-Hong Li, Patrick Edward MacDonald
A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding. Nature communications 15 (1) (2024)
Jessica D Ewald, Yao Lu, Cara E Ellis, Jessica Worton, Jelena Kolic, Shugo Sasaki, Dahai Zhang, Theodore Dos Santos, Aliya F Spigelman, Austin Bautista, Xiao-Qing Dai, James G Lyon, Nancy P Smith, Jordan M Wong, Varsha Rajesh, Han Sun, Seth A Sharp, Jason C Rogalski, Renata Moravcova, Haoning Howard Cen, Jocelyn E Manning Fox, null null, Ella Atlas, Jennifer E Bruin, Erin E Mulvihill, C Bruce Verchere, Leonard J Foster, Anna L Gloyn, James D Johnson, Andrew R Pepper, Francis C Lynn, Jianguo Xia, Patrick Edward MacDonald
HumanIslets: An integrated platform for human islet data access and analysis. bioRxiv : the preprint server for biology (2024)
Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F Spigelman, Xiao-Qing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R Pepper, Leticia Prates Roma, Emmanuel Ampofo, Wen-Hong Li, Patrick Edward MacDonald
A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding. Nature communications 15 (1) (2024)
Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F Spigelman, Xiao-Qing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R Pepper, Leticia Prates Roma, Emmanuel Ampofo, Wen-Hong Li, Patrick Edward MacDonald
A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding. Nature communications 15 (1) (2024)
Jessica D Ewald, Yao Lu, Cara E Ellis, Jessica Worton, Jelena Kolic, Shugo Sasaki, Dahai Zhang, Theodore Dos Santos, Aliya F Spigelman, Austin Bautista, Xiao-Qing Dai, James G Lyon, Nancy P Smith, Jordan M Wong, Varsha Rajesh, Han Sun, Seth A Sharp, Jason C Rogalski, Renata Moravcova, Haoning Howard Cen, Jocelyn E Manning Fox, null null, Ella Atlas, Jennifer E Bruin, Erin E Mulvihill, C Bruce Verchere, Leonard J Foster, Anna L Gloyn, James D Johnson, Andrew R Pepper, Francis C Lynn, Jianguo Xia, Patrick Edward MacDonald
HumanIslets: An integrated platform for human islet data access and analysis. bioRxiv : the preprint server for biology (2024)
Haopeng Lin, Kunimasa Suzuki, Nancy Smith, Xi Li, Lisa Nalbach, Sonia Fuentes, Aliya F Spigelman, Xiao-Qing Dai, Austin Bautista, Mourad Ferdaoussi, Saloni Aggarwal, Andrew R Pepper, Leticia Prates Roma, Emmanuel Ampofo, Wen-Hong Li, Patrick Edward MacDonald
A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding. Nature communications 15 (1) (2024)
Yi-Chun Chen, Austin J Taylor, James M Fulcher, Adam C Swensen, Xiao-Qing Dai, Mitsuhiro Komba, Kenzie L C Wrightson, Kenny Fok, Annette E Patterson, Ramon I Klein Geltink, Patrick Edward MacDonald, Wei-Jun Qian, C Bruce Verchere
Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing but does not lead to spontaneous development of diabetes in mice. Diabetes (2023)
Katia K Mattis, Nicole A J Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Hanice Sun, Jennifer M Ikle, Swaraj Thaman, Antje K Grotz, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E Manning Fox, Jason M Torres, Agata Wesolowska-Andersen, Grace Z Yu, Anubha Mahajan, Anders O Larsson, Patrick Edward MacDonald, Benjamin Davies, Marcel den Hoed, Anna L Gloyn
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia 66 (4) (2023)
Carolin Hoefner, Tenna Holgersen Bryde, Celina Pihl, Sylvia Naiga Tiedemann, Sophie Emilie Bresson, Hajira Ahmed Hotiana, Muhammad Saad Khilji, Theodore Dos Santos, Michele Puglia, Paola Pisano, Mariola Majewska, Julia Durzynska, Kristian Klindt, Justyna Klusek, Marcelo J Perone, Robert Bucki, Per Mårten Hägglund, Pontus Emanuel Gourdon, Kamil Gotfryd, Edyta Urbaniak, Malgorzata Borowiak, Michael Wierer, Patrick Edward MacDonald, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
FK506-Binding Protein 2 Participates in Proinsulin Folding. Biomolecules 13 (1) (2023)
Katia K Mattis, Nicole A J Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Hanice Sun, Jennifer M Ikle, Swaraj Thaman, Antje K Grotz, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E Manning Fox, Jason M Torres, Agata Wesolowska-Andersen, Grace Z Yu, Anubha Mahajan, Anders O Larsson, Patrick Edward MacDonald, Benjamin Davies, Marcel den Hoed, Anna L Gloyn
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia (2023)
Katia K Mattis, Nicole A J Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Hanice Sun, Jennifer M Ikle, Swaraj Thaman, Antje K Grotz, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E Manning Fox, Jason M Torres, Agata Wesolowska-Andersen, Grace Z Yu, Anubha Mahajan, Anders O Larsson, Patrick Edward MacDonald, Benjamin Davies, Marcel den Hoed, Anna L Gloyn
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia (2023)
Katia K Mattis, Nicole A J Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Hanice Sun, Jennifer M Ikle, Swaraj Thaman, Antje K Grotz, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E Manning Fox, Jason M Torres, Agata Wesolowska-Andersen, Grace Z Yu, Anubha Mahajan, Anders O Larsson, Patrick Edward MacDonald, Benjamin Davies, Marcel den Hoed, Anna L Gloyn
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia 66 (4) (2023)
Katia K Mattis, Nicole A J Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Hanice Sun, Jennifer M Ikle, Swaraj Thaman, Antje K Grotz, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E Manning Fox, Jason M Torres, Agata Wesolowska-Andersen, Grace Z Yu, Anubha Mahajan, Anders O Larsson, Patrick Edward MacDonald, Benjamin Davies, Marcel den Hoed, Anna L Gloyn
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia 66 (4) (2023)
Katia K Mattis, Nicole A J Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Hanice Sun, Jennifer M Ikle, Swaraj Thaman, Antje K Grotz, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E Manning Fox, Jason M Torres, Agata Wesolowska-Andersen, Grace Z Yu, Anubha Mahajan, Anders O Larsson, Patrick Edward MacDonald, Benjamin Davies, Marcel den Hoed, Anna L Gloyn
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia (2023)
Katia K Mattis, Nicole A J Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Hanice Sun, Jennifer M Ikle, Swaraj Thaman, Antje K Grotz, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E Manning Fox, Jason M Torres, Agata Wesolowska-Andersen, Grace Z Yu, Anubha Mahajan, Anders O Larsson, Patrick Edward MacDonald, Benjamin Davies, Marcel den Hoed, Anna L Gloyn
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia 66 (4) (2023)
Carolin Hoefner, Tenna Holgersen Bryde, Celina Pihl, Sylvia Naiga Tiedemann, Sophie Emilie Bresson, Hajira Ahmed Hotiana, Muhammad Saad Khilji, Theodore Dos Santos, Michele Puglia, Paola Pisano, Mariola Majewska, Julia Durzynska, Kristian Klindt, Justyna Klusek, Marcelo J Perone, Robert Bucki, Per Mårten Hägglund, Pontus Emanuel Gourdon, Kamil Gotfryd, Edyta Urbaniak, Malgorzata Borowiak, Michael Wierer, Patrick Edward MacDonald, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
FK506-Binding Protein 2 Participates in Proinsulin Folding. Biomolecules 13 (1) (2023)
Carolin Hoefner, Tenna Holgersen Bryde, Celina Pihl, Sylvia Naiga Tiedemann, Sophie Emilie Bresson, Hajira Ahmed Hotiana, Muhammad Saad Khilji, Theodore Dos Santos, Michele Puglia, Paola Pisano, Mariola Majewska, Julia Durzynska, Kristian Klindt, Justyna Klusek, Marcelo J Perone, Robert Bucki, Per Mårten Hägglund, Pontus Emanuel Gourdon, Kamil Gotfryd, Edyta Urbaniak, Malgorzata Borowiak, Michael Wierer, Patrick Edward MacDonald, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
FK506-Binding Protein 2 Participates in Proinsulin Folding. Biomolecules 13 (1) (2023)
Katia K Mattis, Nicole A J Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Hanice Sun, Jennifer M Ikle, Swaraj Thaman, Antje K Grotz, Austin Bautista, Eugenia Mazzaferro, Marta Perez-Alcantara, Jocelyn E Manning Fox, Jason M Torres, Agata Wesolowska-Andersen, Grace Z Yu, Anubha Mahajan, Anders O Larsson, Patrick Edward MacDonald, Benjamin Davies, Marcel den Hoed, Anna L Gloyn
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression. Diabetologia 66 (4) (2023)
Cristiane Dos Santos, Shristi Shrestha, Matthew A Cottam, Guy Perkins, Varda Lev-Ram, Birbickram Roy, Christopher Acree, Keun-Young Kim, Thomas Deerinck, Melanie Cutler, Danielle Dean, Jean Philippe Cartailler, Patrick Edward MacDonald, Martin Hetzer, Mark Ellisman, Rafael Arrojo E Drigo
Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms. bioRxiv : the preprint server for biology (2023)
Carolin Hoefner, Tenna Holgersen Bryde, Celina Pihl, Sylvia Naiga Tiedemann, Sophie Emilie Bresson, Hajira Ahmed Hotiana, Muhammad Saad Khilji, Theodore Dos Santos, Michele Puglia, Paola Pisano, Mariola Majewska, Julia Durzynska, Kristian Klindt, Justyna Klusek, Marcelo J Perone, Robert Bucki, Per Mårten Hägglund, Pontus Emanuel Gourdon, Kamil Gotfryd, Edyta Urbaniak, Malgorzata Borowiak, Michael Wierer, Patrick Edward MacDonald, Thomas Mandrup-Poulsen, Michal Tomasz Marzec
FK506-Binding Protein 2 Participates in Proinsulin Folding. Biomolecules 13 (1) (2023)
Marko Gosak, Richard Yan-Do, Haopeng Lin, Patrick Edward MacDonald, Andraž Stožer
Ca2+ Oscillations, Waves, and Networks in Islets From Human Donors With and Without Type 2 Diabetes. Diabetes 71 (12) (2022)
Shristi Shrestha, Galina Erikson, James Lyon, Aliya F Spigelman, Austin Bautista, Jocelyn E Manning Fox, Cristiane Dos Santos, Maxim Nikolaievich Shokhirev, Jean-Philippe Cartailler, Martin W Hetzer, Patrick Edward MacDonald, Rafael Arrojo E Drigo
Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress. Science advances 8 (40) (2022)
Haopeng Lin, Nancy Smith, Aliya F Spigelman, Kunimasa Suzuki, Mourad Ferdaoussi, Tamadher A Alghamdi, Sophie L Lewandowski, Yaxing Jin, Austin Bautista, Ying Wayne Wang, Jocelyn E Manning Fox, Matthew J Merrins, Jean Buteau, Patrick Edward MacDonald
β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet-Fed Mice. Diabetes 70 (11) (2021)
Mourad Ferdaoussi, Nancy Smith, Haopeng Lin, Austin Bautista, Aliya F Spigelman, James Lyon, XiaoQing Dai, Jocelyn E Manning Fox, Patrick Edward MacDonald
Improved glucose tolerance with DPPIV inhibition requires β-cell SENP1 amplification of glucose-stimulated insulin secretion. Physiological reports 8 (8) (2021)
Courtney Ackeifi, Peng Wang, Esra Karakose, Jocelyn E Manning Fox, Bryan J González, Hongtao Liu, Jessica Wilson, Ethan Swartz, Cecilia Berrouet, Yansui Li, Kunal Kumar, Patrick Edward MacDonald, Roberto Sanchez, Bernard Thorens, Robert J DeVita, Dirk Homann, Dieter Egli, Donald K Scott, Adolfo Garcia-Ocaña, Andrew F Stewart
GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration. Science translational medicine 12 (530) (2021)
Theodore Dos Santos, Patrick Edward MacDonald
Novel mouse model expands potential human α-cell research. Islets 13 (3-4) (2021)
Shara Khan, Mourad Ferdaoussi, Austin Bautista, Valérie Bergeron, Nancy Smith, Vincent Poitout, Patrick Edward MacDonald
A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets. Physiological reports 7 (19) (2020)
Rafael Arrojo E Drigo, Birbickram Roy, Patrick Edward MacDonald
Molecular and functional profiling of human islets: from heterogeneity to human phenotypes. Diabetologia 63 (10) (2020)
Victoria L Tokarz, Patrick Edward MacDonald, Amira Klip
The cell biology of systemic insulin function. The Journal of cell biology 217 (7) (2018)

Patrick Edward MacDonald.css-eqlu8i{font-size:small;padding-left:4px;} (Patrick E MacDonald)

Publication Activity (10 Years)

Top Topics

Top Venues

Patrick Edward MacDonald (Patrick E MacDonald)