Cumulative Mtb infection incidence (measured primarily by TST) among infants with HIV exposure: observational follow-up of an isoniazid prophylaxis trial.
Sylvia M LaCourseJaclyn N EscuderoJerphason MechaA J WarrBarbra A RichardsonNaziat CarimoLisa M CranmerElizabeth Maleche-ObimboDaniel MatemoJohn KinuthiaThomas R HawnGrace John-StewartPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
Cumulative 24-month M. tuberculosis infection incidence (measured primarily by TST) was high among HIV-exposed uninfected infants (8.7/100 person-years [95%CI 6.3-11.9)]. Trend for decreased TST-positivity among infants randomized to isoniazid at 6 weeks of age at trial end (12 months post-enrollment) was not sustained through observational follow-up to 24-months of age.
Keyphrases
- mycobacterium tuberculosis
- hiv infected
- phase iii
- antiretroviral therapy
- phase ii
- hiv positive
- hiv aids
- human immunodeficiency virus
- hiv testing
- pulmonary tuberculosis
- open label
- clinical trial
- study protocol
- hepatitis c virus
- risk factors
- double blind
- men who have sex with men
- placebo controlled
- cross sectional
- randomized controlled trial
- emergency department
- health insurance
- gestational age
- adverse drug
- preterm birth
- electronic health record