Immunophenotype and antitumor activity of cytokine-induced killer cells from patients with hepatocellular carcinoma.
Chan-Keng YangChien-Hao HuangChing-Hsun HuJian-He FangTse-Ching ChenYung-Chang LinYung-Chang LinPublished in: PloS one (2023)
This study revealed that CIK cells from HCC patients possess cytotoxic properties, and express increased levels of effector NK receptors and chemokine molecules and lower levels of suppressive checkpoint receptors. CIK cells can suppress human HCC ex-vivo and in vivo. Future clinical trials of human CIK cell therapy for HCC are warranted.
Keyphrases
- endothelial cells
- clinical trial
- single cell
- high glucose
- induced pluripotent stem cells
- end stage renal disease
- newly diagnosed
- induced apoptosis
- ejection fraction
- dna damage
- pluripotent stem cells
- dendritic cells
- cell therapy
- prognostic factors
- randomized controlled trial
- stem cells
- current status
- regulatory t cells
- mesenchymal stem cells
- diabetic rats
- bone marrow
- drug induced
- phase ii
- double blind