Rapid implementation of a cohort for the study of post-acute sequelae of SARS-CoV-2 infection/COVID-19.
Michael J PelusoJ Daniel KellyScott LuSarah A GoldbergMichelle C DavidsonSujata MathurMatthew S DurstenfeldMatthew A SpinelliRebecca HohViva TaiEmily A FehrmanLeonel TorresYanel HernandezMeghann C WilliamsMireya I ArreguinJennifer A BautistaLynn H NgoMonika DeswalSadie E MunterEnrique O MartinezKhamal A AnglinMariela D RomeroJacqueline TavsPaulina R RugartJessica Y ChenHannah M SansVictoria W MurrayPayton K EllisKevin C DonohueJonathan A MassachiJacob O WeissIrum MehdiJesus Pineda-RamirezAlex F TangMegan WengerMelissa AssenzioYan YuanMelissa KroneRachel L RutishauserIsabel Rodriguez-BarraquerBryan GreenhouseJohn A SaucedaMonica GandhiPriscilla Y HsueTimothy J HenrichSteven G DeeksJeffrey N MartinPublished in: medRxiv : the preprint server for health sciences (2021)
Among a cohort of participants enrolled in the post-acute phase of SARS-CoV-2 infection, we found many with persistent physical symptoms through 8 months following onset of COVID-19 with an impact on self-rated overall health. The presence of participants with and without symptoms and ample biological specimens will facilitate study of PASC pathogenesis. Similar evaluations in a population-representative sample will be needed to estimate the population-level prevalence of PASC.