A Gently Processed Skim Milk-Derived Whey Protein Concentrate for Infant Formula: Effects on Gut Development and Immunity in Preterm Pigs.

Karoline Aasmul-OlsenHalise Gül AkıllıoğluLine Iadsatian ChristiansenKasper Engholm-KellerAnders BrunseDenitsa Vladimirova StefanovaAnn BjørnshaveMie Rostved BechshøftKerstin SkovgaardThomas ThymannPer Torp SangildMarianne Nissen Lund Stine Brandt Bering

Published in: Molecular nutrition & food research (2024)

The gently processed SPC has more native protein, but higher MRP levels than WPC, resulting in similar tolerability but subclinical adverse gut effects in preterm pigs. Additional heat treatment and storage further induce MRP formation, gut inflammation, and intestinal mucosal damage.

Keyphrases

oxidative stress
low birth weight
preterm birth
protein protein
gestational age
amino acid
binding protein
human milk
open label
preterm infants
small molecule
emergency department
randomized controlled trial
heat stress
combination therapy