Initial Riociguat Monotherapy and Transition from Sildenafil to Riociguat in Patients with Idiopathic Pulmonary Arterial Hypertension: Influence on Right Heart Remodeling and Right Ventricular-Pulmonary Arterial Coupling.
Irina N TaranAnna A BelevskayaMarina A SaidovaTamila V MartynyukIrina E ChazovaPublished in: Lung (2018)
These results support the proven efficacy of riociguat in patients with IPAH, including treatment-naïve patients and those switching to riociguat following failure to achieve treatment goals with sildenafil, and suggest that it may be possible to delay disease progression in this patient group.
Keyphrases
- pulmonary hypertension
- pulmonary arterial hypertension
- pulmonary artery
- end stage renal disease
- newly diagnosed
- heart failure
- ejection fraction
- combination therapy
- randomized controlled trial
- case report
- prognostic factors
- public health
- atrial fibrillation
- coronary artery
- room temperature
- global health
- study protocol
- ionic liquid