NSD1 in erythroid differentiation and leukemogenesis.

Samantha Tauchmann Marwa Almosailleakh Juerg Schwaller

Published in: Molecular & cellular oncology (2020)

We have uncovered a novel role for the nuclear receptor-binding SET domain protein 1 (NSD1) in human and murine erythroid differentiation. Mechanistically, we found that the histone methyltransferase activity of NSD1 is essential for chromatin binding, protein interactions and target gene activation of the erythroid transcriptional master regulator GATA1.

Keyphrases

binding protein
transcription factor
gene expression
endothelial cells
genome wide
genome wide identification
dna binding
dna methylation
dna damage
induced pluripotent stem cells
pluripotent stem cells
small molecule
heat shock
heat stress
genome wide analysis