Molecular, Metabolic, and Nutritional Changes after Metabolic Surgery in Obese Diabetic Patients (MoMen): A Protocol for a Multicenter Prospective Cohort Study.
Fazliana MansorZubaidah Nor HanipahBarakatun-Nisak Mohd YusofNur Azlin Zainal AbidinYou Zhuan TanFarah Huda MohkiarAhmad Zamri LiyanaMohd Nawi Mohd NaeemNorazlan Mohmad MisnanHaron AhmadMohd Shazli DramanPoh Yue TsenShu Yu LimTikfu GeePublished in: Metabolites (2023)
Metabolic surgery is an essential option in the treatment of obese patients with type 2 diabetes (T2D). Despite its known advantages, this surgery still needs to be introduced in Malaysia. In this prospective study, the pathophysiological mechanisms at the molecular level will be studied and the metabolomics pathways of diabetes remission will be explored. The present study aims to evaluate the changes in the anthropometric measurements, body composition, phase angle, diet intake, biochemistry parameters, adipokines, microRNA, and metabolomics, both pre- and post-surgery, among obese diabetic patients in Malaysia. This is a multicenter prospective cohort study that will involve obese patients ( n = 102) with a body mass index (BMI) of ≥25 kg/m 2 (Asian BMI categories: WHO/IASO/IOTF, 2000) who will undergo metabolic surgery. They will be categorized into three groups: non-diabetes, prediabetes, and diabetes. Their body composition will be measured using a bioimpedance analyzer (BIA). The phase angle (PhA) data will be analyzed. Venous blood will be collected from each patient for glycated hemoglobin (HbA1c), lipids, liver, renal profile, hormones, adipokines, and molecular and metabolomics analyses. The serum microRNA will be measured. A gene expression study of the adipose tissue of different groups will be conducted to compare the groups. The relationship between the 1HNMR-metabolic fingerprint and the patients' lifestyles and dietary practices will be determined. The factors responsible for the excellent remission of T2D will be explored in this study.
Keyphrases
- body composition
- minimally invasive
- adipose tissue
- coronary artery bypass
- obese patients
- body mass index
- type diabetes
- gene expression
- weight loss
- resistance training
- bariatric surgery
- cardiovascular disease
- bone mineral density
- mass spectrometry
- end stage renal disease
- healthcare
- surgical site infection
- primary care
- glycemic control
- physical activity
- randomized controlled trial
- dna methylation
- chronic kidney disease
- newly diagnosed
- weight gain
- prognostic factors
- high resolution
- ejection fraction
- percutaneous coronary intervention
- acute coronary syndrome
- coronary artery disease
- roux en y gastric bypass
- rheumatoid arthritis
- gastric bypass
- artificial intelligence
- systemic lupus erythematosus
- replacement therapy
- fatty acid