A CRISPR/Cas9 zebrafish lamin A/C mutant model of muscular laminopathy.

Hannah A NicolasKhang HuaHailey QuigleyJoshua IvareFrédérique TessonMarie-Andrée Akimenko

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2021)

This study presents an animal model of skeletal muscle laminopathy where heterozygous and homozygous lmna mutants exhibit prominent skeletal muscle abnormalities during the first week of development. Furthermore, this is the first animal model that potentially implicates Pkc α in muscular laminopathies.

Keyphrases

skeletal muscle
crispr cas
insulin resistance
genome editing
resistance training
early onset
randomized controlled trial
metabolic syndrome
clinical trial
type diabetes
duchenne muscular dystrophy