Accelerate Pheno™ blood culture detection system: a literature review.
Elio CenciRiccardo PaggiGiuseppe V De SocioSilvia BozzaBarbara CamilloniDonatella PietrellaAntonella MencacciPublished in: Future microbiology (2020)
Accelerate Pheno™ (ACC) is a fully automated system providing rapid identification of a panel of bacteria and yeasts, and antimicrobial susceptibility testing of common bacterial pathogens responsible for bloodstream infections and sepsis. Diagnostic accuracy for identification ranges from 87.9 to 100%, and antimicrobial susceptibility testing categorical agreement is higher than 91%. The present review includes peer-reviewed studies on ACC published to date. Both interventional and hypothetical studies evidenced the potential positive clinical role of ACC in the management and therapy of patients with bloodstream infections and sepsis, due to the important reduction in time to report, suggesting a crucial impact on the therapeutic management of these patients, provided the presence of a hospital antimicrobial stewardship program, a 24/7 laboratory operating time and a strict collaboration between clinical microbiologist and clinician. Further prospective multicenter studies are necessary to explore the impact of this system on mortality, length of stay and spread of multidrug-resistant organisms.
Keyphrases
- multidrug resistant
- gram negative
- case control
- end stage renal disease
- acute kidney injury
- intensive care unit
- ejection fraction
- healthcare
- septic shock
- machine learning
- chronic kidney disease
- peritoneal dialysis
- drug resistant
- acinetobacter baumannii
- prognostic factors
- high throughput
- case report
- quality improvement
- cross sectional
- randomized controlled trial
- emergency department
- mesenchymal stem cells
- systematic review
- klebsiella pneumoniae
- adverse drug
- pseudomonas aeruginosa
- single cell
- label free
- drug induced