Polyphenol- and Glucuronoxylan-Rich Fiber Extract from Birch ( Betula sp.) Wood Regulates Colonic Barrier Function and Cell Proliferation in Healthy Rats.
Emma KynkäänniemiJere LindénSuchaya NgambunditLaura Aliisa SaarimäkiDario GrecoHana SlabaMaarit H LahtinenKirsi S MikkonenAnne-Maria PajariPublished in: Journal of agricultural and food chemistry (2024)
Birch wood-derived fiber extracts containing glucuronoxylans (GX) and polyphenols show potential for various food technological applications. This study investigated the effect of two extracts, GXpoly and pureGX, differing in lignin content on colonic barrier function. Healthy rats were fed diets containing 10% GXpoly, pureGX, or cellulose for 4 weeks. Colon crypt depth was lower in the GX groups than in the control group, but in the proximal colon, the result was significant only in GXpoly. An artificial intelligence approach was established to measure the mucus content and goblet cells. In the distal colon, their amounts were higher in the control group than in the GX groups. All diets had a similar effect on the expression of the tight junction proteins occludin, claudin-1, and claudin-7. GXpoly enhanced the fecal IgA production. Our results suggest that GX-rich extracts could support the colonic barrier and work as functional food ingredients in the future.
Keyphrases
- artificial intelligence
- cell proliferation
- ulcerative colitis
- machine learning
- big data
- human health
- induced apoptosis
- deep learning
- weight loss
- ionic liquid
- poor prognosis
- cell cycle arrest
- blood brain barrier
- oxidative stress
- risk assessment
- optical coherence tomography
- cell wall
- current status
- atomic force microscopy
- anti inflammatory
- silver nanoparticles
- climate change
- cell death
- high speed