T cell receptor repertoire sequencing reveals chemotherapy-driven clonal expansion in colorectal liver metastases.

Eirik Høye Vegar Johansen Dagenborg Annette Torgunrud Christin Lund-Andersen Åsmund Avdem Fretland Susanne Lorenz Bjørn Edwin Eivind Hovig Bastian Fromm Else Marit Inderberg Victor Greiff Anne Hansen Ree Norman John Carr

Published in: GigaScience (2023)

TCR repertoire sequencing can be used to quantify T-cell infiltration and clonality in clinical samples. This study provides evidence to support chemotherapy-driven T-cell clonal expansion in CLM in a clinical context.

Keyphrases

liver metastases
single cell
locally advanced
regulatory t cells
radiation therapy
high throughput sequencing