Distinct profile and prognostic impact of body composition changes in idiopathic pulmonary fibrosis and idiopathic pleuroparenchymal fibroelastosis.
Yuzo SuzukiKatsuhiro YoshimuraYasunori EnomotoHideki YasuiHironao HozumiMasato KarayamaKazuki FuruhashiNoriyuki EnomotoTomoyuki FujisawaYutaro NakamuraNaoki InuiTakafumi SudaPublished in: Scientific reports (2018)
Change in body composition with skeletal muscle wasting, a major component of pulmonary cachexia, is associated with mortality in chronic obstructive pulmonary disease and cancer. However, its relevance in interstitial lung diseases (ILDs) remains unclear. We hypothesized changes in body composition would be associated with mortality in ILDs. We measured the cross-sectional-area (ESMCSA) and muscle attenuation (ESMMA) of erector-spinae muscles, as determined by CT-imaging, in patients with idiopathic pulmonary fibrosis (IPF; n = 131) and idiopathic pleuroparenchymal fibroelastosis (iPPFE; n = 43) and controls. Subsequently, implications with prognosis were evaluated. The ESMCSA of ILD patients, but not ESMMA, was significantly smaller than that in controls. Lower ESMCSA with decreased BMI were recorded in iPPFE patients versus IPF patients, whilst IPF patients had decreased ESMCSA without BMI decline. Lower ESMCSA in IPF patients were associated with poorer prognoses. Conversely, decreased ESMMA were associated with worse survival in iPPFE patients. Multivariate analyses showed that ESMCSA in IPF and ESMMA in iPPFE were independent risk factors for mortality. Distinct changes in body composition had prognostic significance among patients with IPF and iPPFE. Lower ESMCSA and ESMMA were independently associated with poor prognosis in IPF and iPPFE, respectively. These results suggest values to measure body composition changes in managing patients with IPF and iPPFE.
Keyphrases
- body composition
- idiopathic pulmonary fibrosis
- end stage renal disease
- skeletal muscle
- ejection fraction
- newly diagnosed
- chronic kidney disease
- poor prognosis
- resistance training
- peritoneal dialysis
- bone mineral density
- cross sectional
- prognostic factors
- rheumatoid arthritis
- type diabetes
- computed tomography
- squamous cell carcinoma
- metabolic syndrome
- pain management
- physical activity
- cardiovascular disease
- long non coding rna
- photodynamic therapy
- patient reported
- fluorescence imaging