Endothelial fatty acid-binding proteins contribute to the pathogenesis of pulmonary hypertension.
Bin LiuDan YiShuai LiKarina RamirezXiaomei XiaYanhong CaoHanqiu ZhaoAnkit TripathiShenfeng QiuMrinalini KalaRuslan RafikovHaiwei GuVinicio de Jesus PerezSarah-Eve LemayChristopher C GlembotskiKenneth S KnoxSebastien BonnetVladimir V KalinichenkoMichael B FallonOlivier BoucheratZhiyu DaiPublished in: bioRxiv : the preprint server for biology (2024)
PH causes aberrant expression of FABP4/5 in pulmonary ECs which leads to enhanced ECs glycolysis and hyperproliferation, contributing to the accumulation of arterial ECs and vascular remodeling and exacerbating the disease.