Dunaimycin C3, a new GRP78 downregulator from Streptomyces sp. RAN389.
Yoichi HayakawaTomohiro YoshidaShoko KimataTeppei KawaharaPublished in: The Journal of antibiotics (2020)
A new member of the dunaimycin family, dunaimycin C3 (2), was isolated from a fermented broth of Streptomyces sp. RAN389. The molecular formula of 2 was established as C42H70O10 by high-resolution FAB-MS, and the structure was elucidated by NMR spectroscopic analyses. Dunaimycin C3 inhibited the expression of the molecular chaperone GRP78 in HT1080 G-L cells in the presence of 10 mM of 2-deoxyglucose with an IC50 of 8.4 nM.
Keyphrases
- high resolution
- induced apoptosis
- endoplasmic reticulum stress
- mass spectrometry
- poor prognosis
- cell cycle arrest
- magnetic resonance
- multiple sclerosis
- cell surface
- molecular docking
- positron emission tomography
- photodynamic therapy
- ms ms
- heat shock protein
- oxidative stress
- cell death
- preterm infants
- cell proliferation
- molecular dynamics simulations
- pet ct