A worldwide ENIGMA study on epilepsy-related gray and white matter compromise across the adult lifespan.
Judy ChenAlexander NgoRaul Rodriguez-CrucesJessica RoyerMaria Eugenia CaligiuriAntonio GambardellaLuis ConchaSimon S KellerFernando CendesClarissa Lin YasudaMarina K M AlvimLeonardo BonilhaEzequiel L GleichgerrchtNiels K FockeBarbara A K KreilkampMartin DominFelix von PodewilsSoenke LangnerChristian RummelRoland WiestPascal MartinKotikalapudi RavitejaBenjamin BenderTerence J O'BrienBenjamin SinclairLucy E VivashPatrick KwanPatricia M DesmondElaine H LuiGian Marco DumaPaolo BonanniAlice BalleriniAnna Elisabetta VaudanoStefano MelettiManuela TondelliSaud AlhusainiColin P DohertyGianpiero L CavalleriNorman DelantyReetta KälviäinenGraeme D JacksonMagdalena KowalczykMario MascalchiMira SemmelrochRhys Huw ThomasHamid Soltanian-ZadehEsmaeil Davoodi-BojdJunsong ZhangMatteo LengeRenzo GuerriniEmanuele BartoliniKhalid HamandiSonya F FoleyTheodor RuberTobias BauerBernd WeberBenoit CaldairouChantal DepondtJulie AbsilSarah J A CarrEugenio AbelaMark P RichardsonOrrin DevinskyHeath R PardoeMariasavina SeverinoPasquale StrianoDomenico TortoraErik KaestnerSean N HattonDonatello ArienzoSjoerd B VosMina RytenPeter Neal TaylorJohn Sidney DuncanChristopher D WhelanMarian GalovicGavin P WinstonSophia I ThomopoulosPaul M ThompsonSanjay M SisodiyaAngelo LabateCarrie R McDonaldLorenzo CaciagliNeda BernasconiAndrea BernasconiSara LariviereDewi SchraderBoris C BernhardtPublished in: bioRxiv : the preprint server for biology (2024)
This study highlights the profound impact of TLE on lifespan changes in grey and white matter structures, with an acceleration of aging-related processes in later decades of life. Our findings motivate future longitudinal studies across the lifespan and emphasize the importance of prompt diagnosis as well as intervention in patients.