Tissue-Free Liquid Biopsies Combining Genomic and Methylation Signals for Minimal Residual Disease Detection in Patients with Early Colorectal Cancer from the UK TRACC Part B Study.

Susanna Slater Annette Bryant Maria Aresu Ruwaida Begum Hsiang-Chi Chen Clare Peckitt Retchel Lazaro-Alcausi Paul Carter Gayathri Anandappa Shelize Khakoo Lucinda Melcher Vanessa Potter Francisca M Marti Joseph Huang Graham Branagan Nicol George Muti Abulafi Sarah Duff Ashraf Raja Ashish Gupta Nicholas West Leslie A Bucheit Thereasa A Rich Ian Chau David Cunningham Naureen Starlingnull null

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Tissue-free MRD detection with longitudinal sampling predicts recurrence in patients with stage I to III CRC without the need for tissue sequencing. The UK TRACC Part C study is currently investigating the potential for ACT de-escalation in patients with undetectable postoperative ctDNA, given the high NPV indicating a low likelihood of residual disease.

Keyphrases