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Transcriptome patterns in hidradenitis suppurativa: support for the role of antimicrobial peptides and interferon pathways in disease pathogenesis.

Victoria K ShanmugamD JonesS McNishMatthew L BendallKeith A Crandall
Published in: Clinical and experimental dermatology (2019)
Evaluation of transcriptome patterns in HS compared with normal skin demonstrated downregulation of the antimicrobial peptide Dermcidin and the innate immune regulator IL-37, as well as upregulation of interferon pathways and pathways of leucocyte activation.
Keyphrases
  • innate immune
  • hidradenitis suppurativa
  • rna seq
  • cell proliferation
  • single cell
  • dendritic cells
  • poor prognosis
  • transcription factor
  • long non coding rna