RNA Helicase DHX37 Facilitates Liver Cancer Progression by Cooperating with PLRG1 to Drive Superenhancer-Mediated Transcription of Cyclin D1.

Zhen LiuYouqiong YeYizhe LiuYanfang LiuHuifang ChenMengting ShenZhen WangShenglin HuangLeng Han Xianghuo He Xiang-Huo He

Published in: Cancer research (2022)

This work characterizes a novel mechanism of superenhancer-driven cyclin D1 upregulation by DHX37 and PLRG1, implicating this pathway as a potential therapeutic target in hepatocellular carcinoma.

Keyphrases

cell cycle
cell proliferation
cell cycle arrest
poor prognosis
signaling pathway
transcription factor
human health
risk assessment