The impact of maternal obesity on childhood neurodevelopment.
Lilin TongBrian T KalishPublished in: Journal of perinatology : official journal of the California Perinatal Association (2020)
There is growing clinical and experimental evidence to suggest that maternal obesity increases children's susceptibility to neurodevelopmental and neuropsychiatric disorders. Given the worldwide obesity epidemic, it is crucial that we acquire a thorough understanding of the available evidence, identify gaps in knowledge, and develop an agenda for intervention. This review synthesizes human and animal studies investigating the association between maternal obesity and offspring brain health. It also highlights key mechanisms underlying these effects, including maternal and fetal inflammation, alterations to the microbiome, epigenetic modifications of neurotrophic genes, and impaired dopaminergic and serotonergic signaling. Lastly, this review highlights several proposed interventions and priorities for future investigation.
Keyphrases
- birth weight
- weight gain
- insulin resistance
- weight loss
- metabolic syndrome
- high fat diet induced
- type diabetes
- pregnancy outcomes
- high fat diet
- randomized controlled trial
- dna methylation
- oxidative stress
- public health
- gene expression
- young adults
- body mass index
- physical activity
- mental health
- current status
- white matter
- brain injury
- global health
- human health
- health information
- blood brain barrier
- preterm birth
- health promotion