Perillyle alcohol and Quercetin ameliorate monocrotaline-induced pulmonary artery hypertension in rats through PARP1-mediated miR-204 down-regulation and its downstream pathway.
Soodeh RajabiHamid NajafipourSaeideh Jafarinejad FarsangiSiyavash JoukarAhmad BeikMaryam IranpourZeinab KordestaniPublished in: BMC complementary medicine and therapies (2020)
PA and QS improved PAH possibly by affecting the expression of PARP1 and miR-204 and their downstream targets, HIF1a and NFATc2. PA and QS may be therapeutic goals in the treatment of PAH.
Keyphrases
- pulmonary artery
- pulmonary hypertension
- pulmonary arterial hypertension
- long non coding rna
- cell proliferation
- coronary artery
- poor prognosis
- long noncoding rna
- dna damage
- dna repair
- blood pressure
- high glucose
- polycyclic aromatic hydrocarbons
- diabetic rats
- endothelial cells
- drug induced
- alcohol consumption
- public health
- global health