The adipokine vaspin is associated with decreased coronary in-stent restenosis in vivo and inhibits migration of human coronary smooth muscle cells in vitro.
Stefan P KastlKatharina M KatsarosKonstantin A KrychtiukGerlinde JägersbergerChristoph KaunKurt HuberJohann WojtaWalter S SpeidlPublished in: PloS one (2020)
We were able to show that the adipokine vaspin selectively inhibits human coronary SMC migration in vitro and has no effect on HUVEC migration. Vaspin had no effect on proliferation of HUVEC which is an important process of the healing of the stented vessel. In addition, the occurrence of ISR after PCI with implantation of drug eluting stents was significantly associated with low vaspin plasma levels before intervention. Determination of vaspin plasma levels before PCI might be helpful in the identification of patients with high risk for development of ISR after stent implantation. In addition, the selective effects of vaspin on smooth muscle cell migration could potentially be used to reduce ISR without inhibition of re-endothelialization of the stented segment.
Keyphrases
- coronary artery disease
- smooth muscle
- cell migration
- coronary artery
- endothelial cells
- percutaneous coronary intervention
- acute myocardial infarction
- acute coronary syndrome
- randomized controlled trial
- risk assessment
- coronary artery bypass grafting
- antiplatelet therapy
- pluripotent stem cells
- heart failure
- aortic stenosis
- st elevation myocardial infarction
- signaling pathway
- aortic valve
- transcatheter aortic valve replacement
- high resolution
- molecularly imprinted
- mass spectrometry