Severe Atelectasis due to Aspirated Valproic Acid Tablet.
Tomomi TanigakiTakunori OgawaSakika NomuraKoki ItoYuhei KurataAkira MatsukidaMorio IshiharaAihide YoshinoAkihiko KawanaYoshifumi KimizukaPublished in: Case reports in pulmonology (2024)
A 60-year-old man treated with valproic acid (VPA) for epilepsy developed atelectasis and respiratory failure after an accidentally aspirated VPA tablet-induced mucus hypersecretion. Following bronchoscopic removal of the aspirated tablet, his respiratory status improved and massive sputum production did not recur. We hypothesized that the aspirated VPA tablet increased the expression of mucin-related genes, thereby increasing mucus production. Our in vitro experiments using a human respiratory epithelial cell line revealed that VPA directly upregulates the airway mucin-related genes. We believe that this is the first case report of aspirated VPA-induced severe atelectasis and respiratory failure, which were successfully treated with the bronchoscopic removal of the VPA tablet.
Keyphrases
- respiratory failure
- extracorporeal membrane oxygenation
- mechanical ventilation
- high glucose
- drug induced
- case report
- endothelial cells
- diabetic rats
- early onset
- cystic fibrosis
- poor prognosis
- mycobacterium tuberculosis
- acute respiratory distress syndrome
- oxidative stress
- long non coding rna
- pulmonary tuberculosis
- binding protein
- pluripotent stem cells