A combination of phenobarbital and the bumetanide derivative bumepamine prevents neonatal seizures and subsequent hippocampal neurodegeneration in a rat model of birth asphyxia.
Marie JohneChristopher KäuferKerstin RömermannBjörn GailusBirthe GerickeWolfgang LöscherPublished in: Epilepsia (2021)
Both bumepamine and DIMAEB are promising tools that may help to develop more effective lead compounds for clinical trials.