IgG and IgA autoantibodies against L1 ORF1p expressed in granulocytes correlate with granulocyte consumption and disease activity in pediatric systemic lupus erythematosus.
Kennedy C UkadikeKathryn NiXiaoxing WangMartin S TaylorJohn LaCavaLauren M PachmanMary EckertAnne StevensChristian LoodTomas MustelinPublished in: Arthritis research & therapy (2021)
Children with active SLE have elevated IgG and IgA autoantibodies against L1 p40, and this protein can be detected in circulating granulocytes in both pediatric and adult SLE patients. P40 expression and autoantibody levels correlate with disease activity. Markers of neutrophil activation and death also correlate with these autoantibodies and with disease activity, suggesting that neutrophils express L1 and are a source of p40.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis patients
- ankylosing spondylitis
- juvenile idiopathic arthritis
- end stage renal disease
- rheumatoid arthritis
- ejection fraction
- newly diagnosed
- poor prognosis
- peritoneal dialysis
- prognostic factors
- young adults
- small molecule
- amino acid
- protein protein
- patient reported