Antioxidant Effects of Baoyuan Decoction on Dysfunctional Erythrocytes in High-Fat Diet-Induced Hyperlipidemic ApoE-/- Mice.
Zhen WuFengyu JinLingxiao WangYunfang ZhaoYong JiangJun LiPeng-Fei TuJiao ZhengPublished in: Oxidative medicine and cellular longevity (2019)
Baoyuan decoction (BYD), a traditional representative formula, has a long usage history in the treatment of cardiovascular diseases. Since the hyperlipidemia-induced dysfunction of erythrocyte is one of the most important causes of cardiovascular diseases, the improving effects of BYD against high-fat diet (HFD) induced the physiological and physical function of the erythrocytic injury and the potential mechanisms were deeply researched in this study. After 6 weeks of drug treatment, all doses of BYD had significantly decreased the lipid peroxidation in plasma of HFD-induced ApoE-/- mice, even if it had not improved the lipid levels. Then, the erythrocyte-related experimental results showed that BYD had reduced erythrocyte osmotic fragility, stabilized erythrocyte membrane skeleton protein 4.2, and reformed the erythrocyte morphological changes by decreasing erythrocyte membrane lipid peroxidation levels. This study demonstrated that BYD may ameliorate the physiological and physical function of erythrocyte in hyperlipidemic mice through the antioxidant effect on erythrocyte membranes.
Keyphrases
- high fat diet
- high fat diet induced
- insulin resistance
- adipose tissue
- cardiovascular disease
- high glucose
- oxidative stress
- diabetic rats
- metabolic syndrome
- type diabetes
- drug induced
- skeletal muscle
- cognitive decline
- fatty acid
- emergency department
- anti inflammatory
- preterm infants
- cross sectional
- human health
- mild cognitive impairment
- amino acid