Plasma fibroblast growth factor 21 levels increase with ectopic fat accumulation and its receptor levels are decreased in the visceral fat of patients with type 2 diabetes.
Eun Shil HongCheong LimHye Yeon ChoiYun Kyung LeeEu Jeong KuJae Hoon MoonKyong Soo ParkHak Chul JangSung Hee ChoiPublished in: BMJ open diabetes research & care (2019)
Human FGF21 resistance in T2DM could result from increases in FGF21-resistant ectopic fat accumulation. Our study provides novel clinical evidence linking FGF21 resistance and T2DM pathogenesis.