Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia.
Princess D RodriguezHana PaculovaSophie KogutJessica L HeathHilde SchjervenSeth E FrietzePublished in: International journal of molecular sciences (2021)
Non-coding RNAs (ncRNAs) comprise a diverse class of non-protein coding transcripts that regulate critical cellular processes associated with cancer. Advances in RNA-sequencing (RNA-Seq) have led to the characterization of non-coding RNA expression across different types of human cancers. Through comprehensive RNA-Seq profiling, a growing number of studies demonstrate that ncRNAs, including long non-coding RNA (lncRNAs) and microRNAs (miRNA), play central roles in progenitor B-cell acute lymphoblastic leukemia (B-ALL) pathogenesis. Furthermore, due to their central roles in cellular homeostasis and their potential as biomarkers, the study of ncRNAs continues to provide new insight into the molecular mechanisms of B-ALL. This article reviews the ncRNA signatures reported for all B-ALL subtypes, focusing on technological developments in transcriptome profiling and recently discovered examples of ncRNAs with biologic and therapeutic relevance in B-ALL.
Keyphrases
- rna seq
- single cell
- acute lymphoblastic leukemia
- long non coding rna
- poor prognosis
- allogeneic hematopoietic stem cell transplantation
- endothelial cells
- papillary thyroid
- genome wide
- binding protein
- squamous cell carcinoma
- randomized controlled trial
- gene expression
- amino acid
- dna methylation
- small molecule
- induced pluripotent stem cells
- human health
- nucleic acid