Pathogenesis of Cardiomyopathy Caused by Variants in ALPK3 , an Essential Pseudokinase in the Cardiomyocyte Nucleus and Sarcomere.

Radhika AgarwalHiroko Wakimoto Joao A PauloQi ZhangDaniel ReichartChristopher N ToepferArun SharmaAngela C TaiMingyue LunJoshua M Gorham Steven R DePalmaSteven P GygiJonathan G Seidman Christine E Seidman

Published in: Circulation (2022)

cardiomyopathy induces ventricular dilatation caused by insufficient myomesin-mediated force buffering and hypertrophy by impairment of sarcomere proteostasis.

Keyphrases

heart failure
left ventricular
copy number
single molecule
angiotensin ii
catheter ablation