Short-chain fatty acids abrogate Japanese encephalitis virus-induced inflammation in microglial cells via miR-200a-3p/ZBTB20/IKβα axis.
Atreye MajumdarIndira Priya Siva VenkateshVivek SwarupAnirban BasuPublished in: mBio (2024)
. Mechanistically, we demonstrate the interaction between miR-200a-3p and ZBTB20 in regulating the canonical nuclear factor kappa B (NF-κB) signaling pathway via transcriptional regulation of Iκβα. Findings of this study pave the way to a better understanding of SCFA mechanisms that can be used to develop strategies against viral neuroinflammation.
Keyphrases
- nuclear factor
- toll like receptor
- signaling pathway
- induced apoptosis
- lps induced
- oxidative stress
- lipopolysaccharide induced
- inflammatory response
- fatty acid
- pi k akt
- cell cycle arrest
- diabetic rats
- sars cov
- traumatic brain injury
- epithelial mesenchymal transition
- endoplasmic reticulum stress
- cognitive impairment
- drug induced
- neuropathic pain
- spinal cord injury
- cell death
- immune response
- cell proliferation
- stress induced