Longitudinal analysis of the lung microbiota of cynomolgous macaques during long-term SHIV infection.
Alison MorrisJoseph N PaulsonHisham TalukderLaura TiptonHeather KlingLijia CuiAdam FitchMihai PopKaren A NorrisElodie GhedinPublished in: Microbiome (2016)
This study is the first to investigate the dynamics of the lung microbiota over time and in response to immunosuppression in a non-human primate model. The persistence of oral bacteria in the lung and their association with obstruction suggest a potential role in pathogenesis. The lung microbiome in the non-human primate is a valuable tool for examining the impact of the lung microbiome in human health and disease.