ADARs regulate cuticle collagen expression and promote survival to pathogen infection.
Alfa DhakalChinnu SalimMary SkellyYarden AmichanAyelet T LammHeather A HundleyPublished in: BMC biology (2024)
Our data uncover a critical role of the C. elegans ADAR family of RNA-binding proteins in promoting cuticular collagen expression, which represents a new post-transcriptional regulatory node that influences the extracellular matrix. In addition, we provide the first evidence that ADAR mutant animals have altered susceptibility to infection with several opportunistic human pathogens, suggesting a broader role of ADARs in altering physical barriers to infection to influence innate immunity.
Keyphrases
- extracellular matrix
- poor prognosis
- endothelial cells
- transcription factor
- gene expression
- lymph node
- mental health
- physical activity
- binding protein
- electronic health record
- long non coding rna
- candida albicans
- wound healing
- gram negative
- antimicrobial resistance
- artificial intelligence
- deep learning
- pluripotent stem cells
- heat stress