TNF-α-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer.

Yujia ZhengYu LiJingyao LianHuiyun YangFeng LiSong ZhaoYu QiYi ZhangLan Huang

Published in: Journal of translational medicine (2019)

Taken together, Tim-3 may play a crucial role to induce NK cell dysfunction in tumor microenvironment and could serve as a potential biomarker for prognosis of esophageal cancer.

Keyphrases

natural killer cells
nk cells
endothelial cells
oxidative stress
high glucose
poor prognosis
diabetic rats
rheumatoid arthritis
induced pluripotent stem cells
pluripotent stem cells
binding protein