Relationship between quantitative strength and functional outcomes in the phase 2 FORTITUDE-ALS trial.

Jeremy M Shefner Bill Jacobsen Stuart Kupfer Fady I MalikLisa MengJenny WeiAndrew A Wolff Stacy A Rudnicki

Published in: Amyotrophic lateral sclerosis & frontotemporal degeneration (2023)

In this analysis of data from an ALS clinical trial, muscle strength quantified by dynamometry was strongly correlated with functional capacity. These results suggest that muscle strength directly relates to specific functions of importance to people with ALS.

Keyphrases

clinical trial
amyotrophic lateral sclerosis
phase ii
study protocol
phase iii
open label
high resolution
electronic health record
randomized controlled trial
big data
machine learning
deep learning