Fady I Malik (Fady Malik)

Publication Activity (10 Years)

Years Active: 2022-2024
Publications (10 Years): 20

Top Topics

Hypertrophic Cardiomyopathy

Myasthenia Gravis

Top Venues

Science translational medicine

The Journal of general physiology

Nature cardiovascular research

European heart journal

This page only lists publications with an associated author ORCID identifier.

Publications

Sandra Donkervoort, Martijn van de Locht, Dario Ronchi, Janine Reunert, Catriona A Mclean, Maha Saad Zaki, Rotem Orbach, Josine M de Winter, Stefan Conijn, Daan Hoomoedt, Osorio Lopes Abath Neto, Francesca Magri, Angela N Viaene, A Reghan Foley, Svetlana Gorokhova, Veronique Bolduc, Ying Hu, Nicole Acquaye, Laura Napoli, Julien H Park, Kalyan Immadisetty, Lee B Miles, Mona Essawi, Salar McModie, Leonardo F Ferreira, Simona Zanotti, Sarah B Neuhaus, Livija Medne, Nagham ElBagoury, Kory R Johnson, Yong Zhang, Nigel G Laing, Mark R Davis, Robert J Bryson-Richardson, Darren T Hwee, James J Hartman, Fady I Malik, Peter Michael Kekenes-Huskey, Giacomo Pietro Comi, Wessam E Sharaf-Eldin, Thorsten Marquardt, Gianina Ravenscroft, Carsten G Bonnemann, Coen A C Ottenheijm
Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease. Science translational medicine 16 (741) (2024)
Ricardo A Galli Caro, Tamara C Borsboom, Charlotte Gineste, Lorenza Brocca, Maira Rossi, Darren T Hwee, Fady I Malik, Roberto Bottinelli, Julien Gondin, Maria-Antonietta Pellegrino, Josine M de Winter, Coen A C Ottenheijm
Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy. The Journal of general physiology 156 (4) (2024)
Caroline J Coats, Ahmad Masri, Michael E Nassif, Roberto Barriales Villa, Michael Arad, Nuno Cardim, Lubna Choudhury, Brian Lee Claggett, Hans-Dirk Düngen, Pablo García-Pavía, Albert A Hagège, James L Januzzi, Matthew Meng Yang Lee, Gregory D Lewis, Chang Sheng Ma, Martin S Maron, Zi Michael Miao, Michelle Michels, Iacopo Olivotto, Artur Oreziak, Anjali Tiku Owens, John A Spertus, Scott D Solomon, Jacob Tfelt Hansen, Marion van Sinttruije, Josef Veselka, Hugh C Watkins, Daniel L Jacoby, Polina German, Stephen B Heitner, Stuart Kupfer, Justin D Lutz, Fady I Malik, Lisa Meng, Amy Wohltman, Theodore P Abraham, null null
Dosing and Safety Profile of Aficamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA-HCM. Journal of the American Heart Association (2024)
James J Hartman, Darren T Hwee, Julien Robert-Paganin, Chihyuan Chuang, Eva R Chin, Samantha Edell, Ken H Lee, Roshni Madhvani, Preeti Paliwal, Julien Pernier, Saswata Sankar Sarkar, Julia Schaletzky, Kristine Schauer, Khanha D Taheri, Jingying Wang, Eddie Wehri, Yangsong Wu, Anne Houdusse, Bradley P Morgan, Fady I Malik
Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy. Nature cardiovascular research 3 (8) (2024)
Ricardo A Galli Caro, Tamara C Borsboom, Charlotte Gineste, Lorenza Brocca, Maira Rossi, Darren T Hwee, Fady I Malik, Roberto Bottinelli, Julien Gondin, Maria-Antonietta Pellegrino, Josine M de Winter, Coen A C Ottenheijm
Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy. The Journal of general physiology 156 (4) (2024)
Sandra Donkervoort, Martijn van de Locht, Dario Ronchi, Janine Reunert, Catriona A Mclean, Maha Saad Zaki, Rotem Orbach, Josine M de Winter, Stefan Conijn, Daan Hoomoedt, Osorio Lopes Abath Neto, Francesca Magri, Angela N Viaene, A Reghan Foley, Svetlana Gorokhova, Veronique Bolduc, Ying Hu, Nicole Acquaye, Laura Napoli, Julien H Park, Kalyan Immadisetty, Lee B Miles, Mona Essawi, Salar McModie, Leonardo F Ferreira, Simona Zanotti, Sarah B Neuhaus, Livija Medne, Nagham ElBagoury, Kory R Johnson, Yong Zhang, Nigel G Laing, Mark R Davis, Robert J Bryson-Richardson, Darren T Hwee, James J Hartman, Fady I Malik, Peter Michael Kekenes-Huskey, Giacomo Pietro Comi, Wessam E Sharaf-Eldin, Thorsten Marquardt, Gianina Ravenscroft, Carsten G Bonnemann, Coen A C Ottenheijm
Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease. Science translational medicine 16 (741) (2024)
Caroline J Coats, Ahmad Masri, Michael E Nassif, Roberto Barriales Villa, Michael Arad, Nuno Cardim, Lubna Choudhury, Brian Lee Claggett, Hans-Dirk Düngen, Pablo García-Pavía, Albert A Hagège, James L Januzzi, Matthew Meng Yang Lee, Gregory D Lewis, Chang Sheng Ma, Martin S Maron, Zi Michael Miao, Michelle Michels, Iacopo Olivotto, Artur Oreziak, Anjali Tiku Owens, John A Spertus, Scott D Solomon, Jacob Tfelt Hansen, Marion van Sinttruije, Josef Veselka, Hugh C Watkins, Daniel L Jacoby, Polina German, Stephen B Heitner, Stuart Kupfer, Justin D Lutz, Fady I Malik, Lisa Meng, Amy Wohltman, Theodore P Abraham, null null
Dosing and Safety Profile of Aficamten in Symptomatic Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA-HCM. Journal of the American Heart Association 13 (15) (2024)
James J Hartman, Darren T Hwee, Julien Robert-Paganin, Chihyuan Chuang, Eva R Chin, Samantha Edell, Ken H Lee, Roshni Madhvani, Preeti Paliwal, Julien Pernier, Saswata Sankar Sarkar, Julia Schaletzky, Kristine Schauer, Khanha D Taheri, Jingying Wang, Eddie Wehri, Yangsong Wu, Anne Houdusse, Bradley P Morgan, Fady I Malik
Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy. Nature cardiovascular research 3 (8) (2024)
James J Hartman, Darren T Hwee, Julien Robert-Paganin, Chihyuan Chuang, Eva R Chin, Samantha Edell, Ken H Lee, Roshni Madhvani, Preeti Paliwal, Julien Pernier, Saswata Sankar Sarkar, Julia Schaletzky, Kristine Schauer, Khanha D Taheri, Jingying Wang, Eddie Wehri, Yangsong Wu, Anne Houdusse, Bradley P Morgan, Fady I Malik
Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy. Nature cardiovascular research 3 (8) (2024)
Ricardo A Galli Caro, Tamara C Borsboom, Charlotte Gineste, Lorenza Brocca, Maira Rossi, Darren T Hwee, Fady I Malik, Roberto Bottinelli, Julien Gondin, Maria-Antonietta Pellegrino, Josine M de Winter, Coen A C Ottenheijm
Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy. The Journal of general physiology 156 (4) (2024)
Sandra Donkervoort, Martijn van de Locht, Dario Ronchi, Janine Reunert, Catriona A Mclean, Maha Saad Zaki, Rotem Orbach, Josine M de Winter, Stefan Conijn, Daan Hoomoedt, Osorio Lopes Abath Neto, Francesca Magri, Angela N Viaene, A Reghan Foley, Svetlana Gorokhova, Veronique Bolduc, Ying Hu, Nicole Acquaye, Laura Napoli, Julien H Park, Kalyan Immadisetty, Lee B Miles, Mona Essawi, Salar McModie, Leonardo F Ferreira, Simona Zanotti, Sarah B Neuhaus, Livija Medne, Nagham ElBagoury, Kory R Johnson, Yong Zhang, Nigel G Laing, Mark R Davis, Robert J Bryson-Richardson, Darren T Hwee, James J Hartman, Fady I Malik, Peter Michael Kekenes-Huskey, Giacomo Pietro Comi, Wessam E Sharaf-Eldin, Thorsten Marquardt, Gianina Ravenscroft, Carsten G Bonnemann, Coen A C Ottenheijm
Pathogenic TNNI1 variants disrupt sarcomere contractility resulting in hypo- and hypercontractile muscle disease. Science translational medicine 16 (741) (2024)
Ricardo A Galli Caro, Tamara C Borsboom, Charlotte Gineste, Lorenza Brocca, Maira Rossi, Darren T Hwee, Fady I Malik, Roberto Bottinelli, Julien Gondin, Maria-Antonietta Pellegrino, Josine M de Winter, Coen A C Ottenheijm
Tirasemtiv enhances submaximal muscle tension in an Acta1:p.Asp286Gly mouse model of nemaline myopathy. The Journal of general physiology 156 (4) (2024)
Marloes van den Berg, Zhonghua Shi, Wout J Claassen, Pleuni Hooijman, Christopher T A Lewis, Jesper Løvind Andersen, Robbert J van der Pijl, Sylvia J P Bogaards, Stefan Conijn, Eva L Peters, Leon P L Begthel, Bas A Uijterwijk, Johan Lindqvist, Paul R Langlais, Armand R J Girbes, Sandra Stapel, Henk L Granzier, Kenneth S Campbell, Weikang Ma, Thomas C Irving, Darren T Hwee, James J Hartman, Fady I Malik, Marinus Paul, Albertus Beishuizen, Julien Ochala, Leo Heunks, Coen A C Ottenheijm
Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients. Science translational medicine 16 (758) (2024)
Marloes van den Berg, Zhonghua Shi, Wout J Claassen, Pleuni Hooijman, Christopher T A Lewis, Jesper Løvind Andersen, Robbert J van der Pijl, Sylvia J P Bogaards, Stefan Conijn, Eva L Peters, Leon P L Begthel, Bas A Uijterwijk, Johan Lindqvist, Paul R Langlais, Armand R J Girbes, Sandra Stapel, Henk L Granzier, Kenneth S Campbell, Weikang Ma, Thomas C Irving, Darren T Hwee, James J Hartman, Fady I Malik, Marinus Paul, Albertus Beishuizen, Julien Ochala, Leo Heunks, Coen A C Ottenheijm
Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients. Science translational medicine 16 (758) (2024)
Jeremy M Shefner, Bill Jacobsen, Stuart Kupfer, Fady I Malik, Lisa Meng, Jenny Wei, Andrew A Wolff, Stacy A Rudnicki
Relationship between quantitative strength and functional outcomes in the phase 2 FORTITUDE-ALS trial. Amyotrophic lateral sclerosis & frontotemporal degeneration (2023)
Jeremy M Shefner, Ammar Al Chalabi, Jinsy A Andrews, Adriano Chio, Mamede de Carvalho, Bettina M Cockroft, Philippe Corcia, Philippe Couratier, Merit E Cudkowicz, Angela Genge, Orla Hardiman, Terry D Heiman-Patterson, Robert David Henderson, Caroline Ingre, Carlayne E Jackson, Wendy Johnston, Noah Lechtzin, Albert C Ludolph, Nicholas J Maragakis, Timothy M Miller, Jesus S Mora, Susanne Petri, Zachary Simmons, Leonard H Van Den Berg, Lorne Zinman, Stuart Kupfer, Fady I Malik, Lisa Meng, Tyrell J Simkins, Jenny Wei, Andrew A Wolff, Stacy A Rudnicki
COURAGE-ALS: a randomized, double-blind phase 3 study designed to improve participant experience and increase the probability of success. Amyotrophic lateral sclerosis & frontotemporal degeneration (2023)
Waly Dioh, Vihang Narkar, Anurag Singh, Fady I Malik, Luigi Ferruci, Cendrine Tourette, Jean Mariani, Rob van Maanen, Roger A Fielding
Novel Potential Targets for Function-Promoting Therapies: Orphan Nuclear Receptors, Anti-inflammatory Drugs, Troponin Activators, Mas Receptor Agonists, and Urolithin A. The journals of gerontology. Series A, Biological sciences and medical sciences 78 (Supplement_1) (2023)
Scott D Solomon, Brian L Claggett, Zi Michael Miao, Rafael Diaz, G Michael Felker, John J V McMurray, Marco Metra, Ramón Corbalán, Gerasimos S Filippatos, Assen R Goudev, Viatcheslav Mareev, Pranas Serpytis, Thomas Suter, Mehmet Birhan Yilmaz, Faiez Zannad, Stuart Kupfer, Stephen B Heitner, Fady I Malik, John R Teerlink
Influence of atrial fibrillation on efficacy and safety of omecamtiv mecarbil in heart failure: the GALACTIC-HF trial. European heart journal 43 (23) (2022)
Marco Metra, Matteo Pagnesi, Brian Lee Claggett, Rafael Díaz, G Michael Felker, John Joseph Valentine McMurray, Scott D Solomon, Diana Bonderman, James C Fang, Cândida Fonseca, Eva Goncalvesova, Jonathan G Howlett, Jing Li, Eileen O'Meara, Zi Michael Miao, Siddique A Abbasi, Stephen B Heitner, Stuart Kupfer, Fady I Malik, John R Teerlink
Effects of omecamtiv mecarbil in heart failure with reduced ejection fraction according to blood pressure: the GALACTIC-HF trial. European heart journal (2022)
Ashley N Sharpe, Maureen S Oldach, Joanna L Kaplan, Victor Rivas, Samantha L Kovacs, Darren T Hwee, Bradley P Morgan, Fady I Malik, Samantha P Harris, Joshua A Stern
Pharmacokinetics of a single dose of Aficamten (CK-274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model. Journal of veterinary pharmacology and therapeutics (2022)